Postdoctoral Researcher

Uconn Health   Farmington, CT   Full-time     Research
Posted on March 20, 2024

Job Title:
Postdoctoral Researcher

Workplace:
The Agmon Lab, part of the Center for Cell Analysis and Modeling at UConn Health, is focused on developing comprehensive computational models to understand cellular behavior at multiple scales. Our projects span the molecular basis of cellular processes to the complex interactions within microbial communities, leveraging our open-source platform, Vivarium, to integrate and simulate these multiscale biological phenomena. Learn more at https://eagmon.github.io/.

Project Description:
We are starting a project aimed at revolutionizing our approach to identifying missing or unknown gene functions using whole-cell models, particularly focused on extending an established whole-cell model of E. coli. By integrating whole-cell modeling with a modular simulation platform and a probabilistic inference workflow, we aim to automate the discovery and curation of gene functions. This project will enhance the predictive accuracy of the E. coli model under various conditions, leveraging extensive datasets and high-performance computing resources for simulation and analysis.

Job Description:
We seek a highly motivated Postdoctoral Researcher to lead the development and implementation of our discovery workflow. The ideal candidate will have a strong background in probabilistic modeling, simulation, and computational biology, with a passion for tackling complex biological questions. The project involves generating and analyzing thousands of model variants, utilizing advanced computational techniques to infer and curate new gene functions, thereby refining the model’s predictive capability across numerous conditions.

Requirements:

  • PhD in Computational Biology, Bioinformatics, Systems Biology, Applied Mathematics, or a related field.
  • Proven experience with probabilistic modeling, simulation, and data analysis.
  • Strong programming skills, preferably in Python.
  • Familiarity with whole-cell modeling, high-performance computing, and bioinformatics databases is a plus.
  • Excellent communication and collaboration skills.

Responsibilities:

  • Develop and implement the simulation-based inference workflow for the discovery of gene functions.
  • Perform simulations of E. coli variants, analyze results, and integrate findings to enhance the model.
  • Collaborate with research teams to intake experimental data and validate model predictions.
  • Publish findings in high-impact journals and present at international conferences.

Benefits:

  • Competitive salary with comprehensive medical and dental insurance.
  • Access to state-of-the-art computational resources and collaboration with leading researchers in the field.
  • Opportunity to contribute to groundbreaking research.
  • Flexible work schedule and a supportive, inclusive lab environment.

Availability:

  • This position is available immediately and will remain open until filled. For further details or to apply, please contact Dr. Eran Agmon at agmon@uchc.edu.

UConn Health is an Affirmative Action/Equal Opportunity Employer M/F/V/PwD.